Seth and Ryan (The OC)
Yah know how they say opposites attract? Well, Seth and Ryan are the epitome of that statement. See, Seth was the nerd with no friends while Ryan was the brooding kid from the wrong neighborhood. The perfect recipe for an instant, lasting bond. Granted it also meant that Seth could talk about himself for hours with little to no reply from Ryan, but hey, it worked. Guys, Seth literally sailed away from home and his childhood crush turned girlfriend when Ryan moved away. Need we elaborate anymore?
Jim and Pam (The Office)
Do we need to say more?! Fine, ~sigh~. Long before Jim and Pam began a relationship, got married, and had kids, they were the best of friends. And they still are. With their inside jokes, air high-fives, and total dorky ways, PB&J are forever the bestest of friends.